Welcome to Our Drug Portal...

Where our latest pre-optimized drug IP
is available for your consideration.

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Our Current Drug Offering: A non-covalent (possibly reversible) antagonist for human monoamine oxidase-B (MAOB) involved in L-dopamine degradation in the brain. MAOB is an extremely important drug target for Parkinson's Disease patients and global sales are increasing as Parkinsons becomes more prevalent, particularly in aging populations. Using an iterative fragment-based strategy, we designed and optimized a novel small molecule for binding into the MAOB catalytic domain. We then compared its docking behavior (binding energies and dissociation constants) to that of known experimental and FDA-approved MAOB inhibitors. Using molecular dynamics, we also analyzed drug-receptor complex stability in physiological saline (0.9wt% NaCl) over ns time scales at 310oK and found the drug to be stably bound. Finally, a complete ADMET profile was developed comparing the new drug with all known MAOB inhibitors. 
We consider this novel MAOB inhibitor to be a highly promising "hit" worthy of conducting followup deep similarity searching and transitioning to experimental laboratory evaluation.
The drug performance metrics are summarized in a 1-page "Prospectus Report" that may be downloaded by clicking on the PDF symbol to the right...
Should you wish to discuss how this unique drug design may be acquired for a one-time fee (no royalty futures), please CONTACT Dr. Harry Ridgway.
Important Note: The drug structure is not disclosed in the prospectus, only comparative performance results. The drug strucure and all raw supporting data will be exclusively released to the buyer following confirmation of payment recieved.
What our clients receive in confidence when they purchase our drug IP...
  1. Fully executed exclusive sales agreement descibing product IP, conveyance method, price/terms, payment method, non-disclosure conditions, identities of parties to the contract, and other conditions.
  2. Drug prospectus descibing in-silico drug performance compared to experimentally-verified and/or FDA-approved drugs that compete for the same target receptor(s). The prospectus provides a summary of drug docking results, drug-target complex stability computed by MD simulations in physiological saline, and an extensive ADMET profile, including synthetic accessibility.
  3. All supporting raw data used to generate the performance prospectus, including MD trajectories in GROMACS XTC, AMBER MDCrd, Yasara SIM, or simply PDB format.
  4. Complete description of methods and strategies employed to generate the IP.
  5. Molecular structure of the drug including its calculated electronic properties (orbital energies, electron distribution, and so forth.
  6. Up to 8 hours of consulting services provided at 50% of our normal rate in support of IP transitioning (e.g., for further target optimization or refinement, similarity searches over large chemical space, etc.
  7. Additional unlimited consulting services made available at our normal competitive rate to provide further detailed computational studies of the compound.
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